Here’s a good question, what do you get if you mix Tylenol with Motrin? One thing is sure, you won’t obtain Vicodin out of this pill combination. Vicodin is a combination of hydrocodone and acetaminophen (Tylenol), and is also available as Vicoprophen mixed with Ibuprophen (which is Motrin).

So by combining Motrin with Tylenol you would get some pain relief but not as much as Vicodin offers – Tylenol will offer some pain relief (and sometimes reduces fever), while Motrin is anti-inflammatory. It’s ok to take them together but not to exceed the amount of Tylenol since large amounts can cause liver damage.

No it’s not safe to combine Vicodin and Tylenol PM. The reason is that Vicodin already contains acetaminophen (which is basically Tylenol), so combining the Vicodin and Tylenol PM would result in taking a higher dose of acetaminophen. Quantities over 4 grams of acetaminophen daily may result in liver problems, so you should avoid taking Vicodin and Tylenol PM together just for this reason. Take one or the other, depending on what the doctor prescribed.