No it’s not safe to combine Vicodin and Tylenol PM. The reason is that Vicodin already contains acetaminophen (which is basically Tylenol), so combining the Vicodin and Tylenol PM would result in taking a higher dose of acetaminophen. Quantities over 4 grams of acetaminophen daily may result in liver problems, so you should avoid taking Vicodin and Tylenol PM together just for this reason. Take one or the other, depending on what the doctor prescribed.

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